This text is based on a reflection on the context and meaning of Maurice Merleau-Ponty’s visit to Mexico in February-March 1949 and the lectures he gave at the Faculty of Philosophy and Letters of the National Autonomous University of Mexico (UNAM). I rely on the information, analysis and notes of Merleau-Ponty that Michel Dalissier offers us in his book Inédits I-II. I devote myself particularly to commenting on the cultural experience that this trip represented for Merleau-Ponty – his relationship with the Mexican philosophy of the Hiperión group – as well as his conception of culture and the relationship between cultures that he exhibits at the time and in the general construction of his own work and philosophy. I support the thesis that the question of a plurality of cultures and interculturality can only be thought in a rigorous way – without falling into cultural relativism or an abstract universalism – through a phenomenological-existential reformulation of the « universal, » as Merleau-Ponty outlines it in the Mexico Conferences.