In this paper, we evaluate the project of resurgence of metaphysics based on the pecularity of the quantum domain, a project that is supported by some contemporary philosophers. Beyond the general arguments against scientific realism that are still applicable here, we show that this project is faced with the three following issues that, we believe, make it unrealizable: (a) the problem raised by the realistic interpretation of the wave function, as a description of a ‘concrete physical fact’ of the independent reality; (b) the lack of any experimental counterpart of the (non-local) hidden variables quantum theories, and, in some cases, their incompatibility with the quantum predictions; and (c) the fact that the key-properties of quantum phenomena, like their non-locality, essentially depend on the observables that are used for their description and cannot then be assigned to any ‘independent’ reality.