This article provides a review of A Buddhist Theory of Semiotics by Fabio Rambelli (2013) while also broadening the scope of its evaluation to the review author’s own considerations “around” semiotics and Buddhism. After summarizing the general structure of the book, this review provides a qualitative evaluation of the book’s treatment of these two major themes: Buddhism and semiotics. It then approaches the question of interdisciplinarity, both in general and in relation to the book in particular. It discusses the two great anthropological perspectives: the emic (or external approach to a studied culture) and the etic (or internal approach to a studied culture). Finally, this review identifies three major ways of conceiving semiotics and the semiotic in relation to three spheres or levels (physical, semiotic and representational).